Sfoglia per Autore
Caspase-dependent cleavage of 170-kDa P-glycoprotein during apoptosis of human T-lymphoblastoid CEM cells.
2006-01-01 Mantovani, I; Cappellini, Alessandra; Tazzari, Pl; Papa, Veronica; Cocco, L; Martelli, Am
The Akt/mammalian target of rapamycin signal transduction pathway is activated in high-risk myelodysplastic syndromes and influences cell survival and proliferation.
2007-01-01 Follo, My; Mongiorgi, S; Bosi, C; Cappellini, Alessandra; Finelli, C; Chiarini, F; Papa, Veronica; Libra, M; Martinelli, G; Cocco, L; Martelli, Am
Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blasts.
2007-01-01 Tazzari, P. L.; Cappellini, Alessandra; Ricci, F.; Evangelisti, C.; Papa, Veronica; Grafone, T.; Martinelli, G.; Conte, R.; Cocco, L.; Mccubrey, J. A.; Martelli, A. M.
Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor (2S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-cell acute lymphoblastic leukemia.
2008-01-01 Falà, F; Blalock, Wl; Tazzari, Pl; Cappellini, Alessandra; Chiarini, F; Martinelli, G; Tafuri, A; Mccubrey, Ja; Cocco, L; Martelli, Am
Radiobiologic response of medulloblastoma cell lines: involvement of beta-catenin?
2008-01-01 Salaroli, R; TOMASO T, Di; Ronchi, A; Ceccarelli, C; Cammelli, S; Cappellini, Alessandra; Martinelli, Gn; Barbieri, E; Giangaspero, F; Cenacchi, G.
Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells
2008-01-01 Papa, Veronica; P. L., Tazzari; F., Chiarini; Cappellini, Alessandra; F., Ricci; A. M., Billi; C., Evangelisti; E., Ottaviani; G., Martinelli; N., Testoni; J. A., Mccubrey; A. M., Martelli
The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism.
2008-01-01 Chiarini, F; DEL SOLE, M; Mongiorgi, S; Gaboardi, Gc; Cappellini, Alessandra; Mantovani, I; Follo, My; Mccubrey, Ja; Martelli, Am
The cyclin-dependent kinase inhibitor roscovitine and the nucleoside analog sangivamycin induce apoptosis in caspase-3 deficient breast cancer cells independent of caspase mediated P-glycoprotein cleavage: implications for therapy of drug resistant breast cancers.
2009-01-01 Cappellini, Alessandra; Chiarini, F; Ognibene, A; Mccubrey, Ja; Martelli, Am
Widespread impairment of cell proliferation in the neonate Ts65Dn mouse, a model for Down syndrome.
2009-01-01 Contestabile, A; Fila, T; Cappellini, Alessandra; Bartesaghi, R; Ciani, E.
The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling network in normal myelopoiesis and leukemogenesis.
2010-01-01 Martelli, Am; Evangelisti, C; Chiarini, F; Grimaldi, C; Cappellini, Alessandra; Ognibene, A; Mccubrey, J. A.
Erucylphosphohomocholine, the first intravenously applicable alkylphosphocholine, is cytotoxic to acute myelogenous leukemia cells through JNK- and PP2A-dependent mechanisms.
2010-01-01 Martelli, Am; Papa, Veronica; Tazzari, Pl; Ricci, F; Evangelisti, C; Chiarini, F; Grimaldi, C; Cappellini, Alessandra; Martinelli, G; Ottaviani, E; Pagliaro, P; Horn, S; Bäsecke, J; Lindner, Lh; Eibl, H; Mccubrey, Ja
Targeting the liver kinaseB1/AMP-activated protein kinasepathway as a therapeutic strategyfor hematological malignancies
2012-01-01 Martelli, A. M.; Chiarini, F.; Evangelisti, C.; Ognibene, A.; Bressanin, D.; Billi, A. M.; Manzoli, L.; Cappellini, Alessandra; Mccubrey, J. A.
A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia.
2012-01-01 Chiarini, F; Lonetti, A; Teti, G; Orsini, E; Bressanin, D; Cappellini, Alessandra; Ricci, F; Tazzari, Pl; Ognibene, A; Falconi, M; Pagliaro, P; Iacobucci, I; Martinelli, G; Amadori, S; Mccubrey, Ja; Martelli, A. M.
Two hits are better than one: targeting both phosphatidylinositol3-kinase and mammalian target of rapamycin as a therapeuticstrategy for acute leukemia treatment
2012-01-01 Martelli, A. M.; Chiarini, F.; Evangelisti, C.; Cappellini, Alessandra; Buontempo, F.; Bressanin, D.; Fini, M.; Mccubrey, J. A.
Therapeutic potential of targeting mTOR in T-cell acute lymphoblastic leukemia (Review)
2014-01-01 Camilla, Evangelisti; Cecilia, Evangelisti; Francesca, Chiarini; Annalisa, Lonetti; Francesca, Buontempo; Daniela, Bressanin; Cappellini, Alessandra; Ester, Orsini; JAMES A., Mccubrey; ALBERTO M., Martelli
Therapeutic targeting of Polo-like kinase-1 and Aurora kinases in T-cell acute lymphoblastic leukemia
2014-01-01 Antonino Maria, Spartà; Daniela, Bressanin; Francesca, Chiarini; Annalisa, Lonetti; Cappellini, Alessandra; Cecilia, Evangelisti; Camilla, Evangelisti; Fraia, Melchionda; Andrea, Pession; Alice, Bertaina; Franco, Locatelli; James A., Mccubrey; Alberto M., Martelli
Cytotoxic activity of the casein kinase 2 inhibitor CX-4945 against T-cell acute lymphoblastic leukemia: targeting the unfolded protein response signaling
2014-01-01 F., Buontempo; E., Orsini; Lr, Martins; I., Antunes; A., Lonetti; F., Chiarini; G., Tabellini; C., Evangelisti; C., Evangelisti; F., Melchionda; A., Pession; A., Bertaina; F., Locatelli; Ja, Mccubrey; Cappellini, Alessandra; Jt, Barata; Am, Martelli
Targeting Signaling Pathways in T-cell acute lymphoblastic leukemia initiating cells
2014-01-01 Alberto M., Martelli; Annalisa, Lonetti; Francesca, Buontempo; Francesca, Ricci; Pier Luigi, Tazzari; Camilla, Evangelisti; Daniela, Bressanin; Cappellini, Alessandra; Ester, Orsini; Francesca, Chiarini
PI3K paninhibition impairs more efficiently proliferation and survival of T-cell acute lymphoblastic leukemia cell lines when compared to isoform-selective PI3K inhibitors
2015-01-01 Annalisa, Lonetti; Cappellini, Alessandra; Antonino Maria, Spartà; Francesca, Chiarini; Francesca, Buontempo1; Camilla, Evangelisti; Cecilia, Evangelisti; Ester, Orsini; James A., Mccubrey; Alberto Maria, Martelli
Synergistic cytotoxic effects of bortezomib and CK2 inhibitor CX-4945 in acute lymphoblastic leukemia: turning off the prosurvival ER chaperone BIP/Grp78 and turning on the proapoptotic NF-κB
2016-01-01 Buontempo, F; Orsini, E; Lonetti, A; Cappellini, Alessandra; Chiarini, F; Evangelisti, C; Evangelisti, C; Melchionda, F; Pession, A; Bertaina, A; Locatelli, F; Bertacchini, J; Neri, Lm; Mccubrey, Ja; Martelli, A. m. 1.
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Caspase-dependent cleavage of 170-kDa P-glycoprotein during apoptosis of human T-lymphoblastoid CEM cells. | 1-gen-2006 | Mantovani, I; Cappellini, Alessandra; Tazzari, Pl; Papa, Veronica; Cocco, L; Martelli, Am | |
| The Akt/mammalian target of rapamycin signal transduction pathway is activated in high-risk myelodysplastic syndromes and influences cell survival and proliferation. | 1-gen-2007 | Follo, My; Mongiorgi, S; Bosi, C; Cappellini, Alessandra; Finelli, C; Chiarini, F; Papa, Veronica; Libra, M; Martinelli, G; Cocco, L; Martelli, Am | |
| Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blasts. | 1-gen-2007 | Tazzari, P. L.; Cappellini, Alessandra; Ricci, F.; Evangelisti, C.; Papa, Veronica; Grafone, T.; Martinelli, G.; Conte, R.; Cocco, L.; Mccubrey, J. A.; Martelli, A. M. | |
| Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor (2S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-cell acute lymphoblastic leukemia. | 1-gen-2008 | Falà, F; Blalock, Wl; Tazzari, Pl; Cappellini, Alessandra; Chiarini, F; Martinelli, G; Tafuri, A; Mccubrey, Ja; Cocco, L; Martelli, Am | |
| Radiobiologic response of medulloblastoma cell lines: involvement of beta-catenin? | 1-gen-2008 | Salaroli, R; TOMASO T, Di; Ronchi, A; Ceccarelli, C; Cammelli, S; Cappellini, Alessandra; Martinelli, Gn; Barbieri, E; Giangaspero, F; Cenacchi, G. | |
| Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells | 1-gen-2008 | Papa, Veronica; P. L., Tazzari; F., Chiarini; Cappellini, Alessandra; F., Ricci; A. M., Billi; C., Evangelisti; E., Ottaviani; G., Martinelli; N., Testoni; J. A., Mccubrey; A. M., Martelli | |
| The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism. | 1-gen-2008 | Chiarini, F; DEL SOLE, M; Mongiorgi, S; Gaboardi, Gc; Cappellini, Alessandra; Mantovani, I; Follo, My; Mccubrey, Ja; Martelli, Am | |
| The cyclin-dependent kinase inhibitor roscovitine and the nucleoside analog sangivamycin induce apoptosis in caspase-3 deficient breast cancer cells independent of caspase mediated P-glycoprotein cleavage: implications for therapy of drug resistant breast cancers. | 1-gen-2009 | Cappellini, Alessandra; Chiarini, F; Ognibene, A; Mccubrey, Ja; Martelli, Am | |
| Widespread impairment of cell proliferation in the neonate Ts65Dn mouse, a model for Down syndrome. | 1-gen-2009 | Contestabile, A; Fila, T; Cappellini, Alessandra; Bartesaghi, R; Ciani, E. | |
| The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling network in normal myelopoiesis and leukemogenesis. | 1-gen-2010 | Martelli, Am; Evangelisti, C; Chiarini, F; Grimaldi, C; Cappellini, Alessandra; Ognibene, A; Mccubrey, J. A. | |
| Erucylphosphohomocholine, the first intravenously applicable alkylphosphocholine, is cytotoxic to acute myelogenous leukemia cells through JNK- and PP2A-dependent mechanisms. | 1-gen-2010 | Martelli, Am; Papa, Veronica; Tazzari, Pl; Ricci, F; Evangelisti, C; Chiarini, F; Grimaldi, C; Cappellini, Alessandra; Martinelli, G; Ottaviani, E; Pagliaro, P; Horn, S; Bäsecke, J; Lindner, Lh; Eibl, H; Mccubrey, Ja | |
| Targeting the liver kinaseB1/AMP-activated protein kinasepathway as a therapeutic strategyfor hematological malignancies | 1-gen-2012 | Martelli, A. M.; Chiarini, F.; Evangelisti, C.; Ognibene, A.; Bressanin, D.; Billi, A. M.; Manzoli, L.; Cappellini, Alessandra; Mccubrey, J. A. | |
| A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia. | 1-gen-2012 | Chiarini, F; Lonetti, A; Teti, G; Orsini, E; Bressanin, D; Cappellini, Alessandra; Ricci, F; Tazzari, Pl; Ognibene, A; Falconi, M; Pagliaro, P; Iacobucci, I; Martinelli, G; Amadori, S; Mccubrey, Ja; Martelli, A. M. | |
| Two hits are better than one: targeting both phosphatidylinositol3-kinase and mammalian target of rapamycin as a therapeuticstrategy for acute leukemia treatment | 1-gen-2012 | Martelli, A. M.; Chiarini, F.; Evangelisti, C.; Cappellini, Alessandra; Buontempo, F.; Bressanin, D.; Fini, M.; Mccubrey, J. A. | |
| Therapeutic potential of targeting mTOR in T-cell acute lymphoblastic leukemia (Review) | 1-gen-2014 | Camilla, Evangelisti; Cecilia, Evangelisti; Francesca, Chiarini; Annalisa, Lonetti; Francesca, Buontempo; Daniela, Bressanin; Cappellini, Alessandra; Ester, Orsini; JAMES A., Mccubrey; ALBERTO M., Martelli | |
| Therapeutic targeting of Polo-like kinase-1 and Aurora kinases in T-cell acute lymphoblastic leukemia | 1-gen-2014 | Antonino Maria, Spartà; Daniela, Bressanin; Francesca, Chiarini; Annalisa, Lonetti; Cappellini, Alessandra; Cecilia, Evangelisti; Camilla, Evangelisti; Fraia, Melchionda; Andrea, Pession; Alice, Bertaina; Franco, Locatelli; James A., Mccubrey; Alberto M., Martelli | |
| Cytotoxic activity of the casein kinase 2 inhibitor CX-4945 against T-cell acute lymphoblastic leukemia: targeting the unfolded protein response signaling | 1-gen-2014 | F., Buontempo; E., Orsini; Lr, Martins; I., Antunes; A., Lonetti; F., Chiarini; G., Tabellini; C., Evangelisti; C., Evangelisti; F., Melchionda; A., Pession; A., Bertaina; F., Locatelli; Ja, Mccubrey; Cappellini, Alessandra; Jt, Barata; Am, Martelli | |
| Targeting Signaling Pathways in T-cell acute lymphoblastic leukemia initiating cells | 1-gen-2014 | Alberto M., Martelli; Annalisa, Lonetti; Francesca, Buontempo; Francesca, Ricci; Pier Luigi, Tazzari; Camilla, Evangelisti; Daniela, Bressanin; Cappellini, Alessandra; Ester, Orsini; Francesca, Chiarini | |
| PI3K paninhibition impairs more efficiently proliferation and survival of T-cell acute lymphoblastic leukemia cell lines when compared to isoform-selective PI3K inhibitors | 1-gen-2015 | Annalisa, Lonetti; Cappellini, Alessandra; Antonino Maria, Spartà; Francesca, Chiarini; Francesca, Buontempo1; Camilla, Evangelisti; Cecilia, Evangelisti; Ester, Orsini; James A., Mccubrey; Alberto Maria, Martelli | |
| Synergistic cytotoxic effects of bortezomib and CK2 inhibitor CX-4945 in acute lymphoblastic leukemia: turning off the prosurvival ER chaperone BIP/Grp78 and turning on the proapoptotic NF-κB | 1-gen-2016 | Buontempo, F; Orsini, E; Lonetti, A; Cappellini, Alessandra; Chiarini, F; Evangelisti, C; Evangelisti, C; Melchionda, F; Pession, A; Bertaina, A; Locatelli, F; Bertacchini, J; Neri, Lm; Mccubrey, Ja; Martelli, A. m. 1. |
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