The correct execution of morphogenetic patterns and the homeostatic control of tissue integrity require that cell proliferation be tightly balanced against cell differentiation and death. Among cell-intrinsic mechanisms deputed to restraining cell proliferation, negative feedback loops have a prominent role, given their ability to operate on sensing the generation and/or accumulation of intracellular signals.
A pervasive role for MIG6 in restraining cell proliferation
CASTELLANI, Loriana;
2014-01-01
Abstract
The correct execution of morphogenetic patterns and the homeostatic control of tissue integrity require that cell proliferation be tightly balanced against cell differentiation and death. Among cell-intrinsic mechanisms deputed to restraining cell proliferation, negative feedback loops have a prominent role, given their ability to operate on sensing the generation and/or accumulation of intracellular signals.File in questo prodotto:
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